Detalhe da pesquisa
1.
Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.
Mol Cell
; 79(5): 846-856.e8, 2020 09 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32755594
2.
Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.
EMBO J
; 41(4): e106825, 2022 02 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35023164
3.
Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.
PLoS Genet
; 18(11): e1010506, 2022 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36441670
4.
Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.
EMBO J
; 39(21): e103420, 2020 11 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32935380
5.
No correlative evidence of costs of infection or immunity on leucocyte telomere length in a wild population of Soay sheep.
Proc Biol Sci
; 291(2020): 20232946, 2024 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-38565156
6.
A CRISPR base editing approach for the functional assessment of telomere biology disorder-related genes in human health and aging.
Biogerontology
; 25(2): 361-378, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38310618
7.
Heritable variation in telomere length predicts mortality in Soay sheep.
Proc Natl Acad Sci U S A
; 118(15)2021 04 13.
Artigo
Inglês
| MEDLINE | ID: mdl-33876756
8.
The association between female reproductive performance and leukocyte telomere length in wild Soay sheep.
Mol Ecol
; 31(23): 6184-6196, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34514660
9.
CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation.
PLoS Comput Biol
; 17(10): e1009482, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34679099
10.
Break-induced replication requires DNA damage-induced phosphorylation of Pif1 and leads to telomere lengthening.
PLoS Genet
; 10(10): e1004679, 2014 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-25329304
11.
Defective repair of uracil causes telomere defects in mouse hematopoietic cells.
J Biol Chem
; 290(9): 5502-11, 2015 Feb 27.
Artigo
Inglês
| MEDLINE | ID: mdl-25572391
12.
Cancer: Trouble upstream.
Nature
; 495(7441): 320-1, 2013 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-23518559
13.
Native gel electrophoresis of human telomerase distinguishes active complexes with or without dyskerin.
Nucleic Acids Res
; 40(5): e36, 2012 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-22187156
14.
Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions.
J Gerontol A Biol Sci Med Sci
; 2024 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-38486371
15.
Haploinsufficiency and telomere length homeostasis.
Mutat Res
; 730(1-2): 37-42, 2012 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22100521
16.
The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization.
Nucleic Acids Res
; 38(6): 2019-35, 2010 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-20034955
17.
Tieing together loose ends: telomere instability in cancer and aging.
Mol Oncol
; 16(18): 3380-3396, 2022 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35920280
18.
The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis.
BMC Mol Biol
; 12: 45, 2011 Oct 18.
Artigo
Inglês
| MEDLINE | ID: mdl-22011238
19.
Catechin from Burkea africana Hook. Exhibits in vitro inhibition of human telomerase activity.
Nat Prod Res
; 35(24): 6175-6179, 2021 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-33930985
20.
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.
Aging Cell
; 20(4): e13331, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33660365